Kristin Scaplen, Assistant Professor, grew up in Connecticut, not far from the Rhode Island border and has lived in New England for much of her life. She received a B.S. in Biology and a B.S. in Psychology from the University of Connecticut and her PhD in Neuroscience from Brown University. Prior to coming to Bryant, she spent her postdoc using sophisticated neurogenetic tools to study the persistence of memory in the context of alcohol use. She intends to continue investigating how neural circuits for pathologic memories are established and change with experience to ultimately guide maladaptive reward seeking.
Ph D, Brown University
B Sc, University of Connecticut
B Sc, University of Connecticut
Scaplen, K. M.,Talay, M.,Fisher, J. D.,Cohn, R.,Sorkaç, A.,Aso, Y.,Barnea, G.,Kaun, K. R., Transsynaptic mapping of Drosophila mushroom body output neurons, eLife, 2021.
Scaplen, K.,Petruccelli, E., Receptors and Channels Associated with Alcohol Use: Contributions from Drosophila, Neuroscience Insights, 2021.
Scaplen, K. M.,Talay, M.,Nuñez, K. M.,Salamon, S.,Waterman, A. G.,Gang, S.,Song, S. L.,Barnea, G.,Kaun, K. R., Circuits that encode and guide alcohol-associated preference, eLife, 2020.
Scaplen, K.,Mei, N. J.,Bounds, H. A.,Song, S. L.,Azanchi, R.,Kaun, K. R., Automated real-time quantification of group locomotor activity in Drosophila melanogaster, Scientific Reports, 2019.
Scaplen, K.,Talay, M.,Salamon, S.,Nuñez, K. M.,Waterman, A. G.,Gang, S.,Song, S. L.,Barnea, G.,Kaun, K. R., Circuits that encode and predict alcohol associated preference, BioRxiv/Cold Spring Harbor Laboratory, 2019.
Scaplen, K.,Agster, K. L.,Burwell, R. D., Anatomy of the Hippocampus and the Declarative Memory System ☆, Elsevier, 2017.
Scaplen, K.,Ramesh, R. N.,Nadvar, N.,Ahmed, O. J.,Burwell, R. D., Inactivation of the Lateral Entorhinal Area Increases the Influence of Visual Cues on Hippocampal Place Cell Activity, Frontiers in Systems Neuroscience, 2017.
Scaplen, K.,Kaun, K. R., Reward from bugs to bipeds: a comparative approach to understanding how reward circuits function, Journal of Neurogenetics, 2016.
Scaplen, K.,Gulati, A. A.,Heimer-McGinn, V. L.,Burwell, R. D., Objects and landmarks: Hippocampal place cells respond differently to manipulations of visual cues depending on size, perspective, and experience, Hippocampus, 2014.
Furtak, S. C.,Cho, C. W.,Kerr, K.,Barredo, J. L.,Alleyne, J. E.,Patterson, Y. R.,Burwell, R. D., The Floor Projection Maze: A novel behavioral apparatus for presenting visual stimuli to rats, Journal of Neuroscience Methods/Elsevier, 2009.
Lewis, M. C.,Kerr (Scaplen), K. M.,Orr, P. T.,Frick, K. M., Estradiol-induced enhancement of object memory consolidation involves NMDA receptors and protein kinase A in the dorsal hippocampus of female C57BL/6 mice., Behavioral Neuroscience, 2008.
Gresack, J. E.,Kerr (Scaplen), K. M.,Frick, K. M., Life-long environmental enrichment differentially affects the mnemonic response to estrogen in young, middle-aged, and aged female mice, Neurobiology of Learning and Memory, 2007.
Gresack, J. E.,Kerr (Scaplen), K. M.,Frick, K. M., Short-term environmental enrichment decreases the mnemonic response to estrogen in young, but not aged, female mice, Brain Research, 2007.
Kerr (Scaplen), K. M.,Agster, K. L.,Furtak, S. C.,Burwell, R. D., Functional neuroanatomy of the parahippocampal region: The lateral and medial entorhinal areas, Hippocampus, 2007.
Neuroscience, Psychology, Learning and Memory, Sensation and Perception, Neurogenetics
I have a long-standing interest in understanding neural circuitry mechanisms underlying learning and memory across species. I currently use a multidisciplinary approach to investigate the mechanisms of learning and memory and understand how they are disrupted by drugs of abuse or other maladaptive conditions. The focus of my work is to understand how neural circuits for pathologic memories are established and change with experience to ultimately guide maladaptive reward seeking. My long-term research goal is to capitalize on the <i>Drosophila </i>model to reveal general circuitry principles for how circuits function and change with experience in adaptive and maladaptive models to better understand how local circuits function in the broader context of the mammalian brain.<br>
Genetics Society of America
International Behavioral and Neural Genetics Society
Brown University Chapter of Sigma Xi
Society for Neuroscience